Liver-specific expression of a Qa-encoded class I gene is associated with DNA hypomethylation.
نویسندگان
چکیده
DNA methylation of two murine major histocompatibility complex (H-2) class I genes was examined in hybridizations to MspI and HpaII chromosomal DNA restriction digests. Q10, which exhibits liver-specific expression, and H-2Kb, a transplantation antigen gene, were examined in liver, spleen, thymus, and cell-line DNAs. Unmethylated Q10 gene sequences were detected only in the liver, whereas the H-2Kb gene was unmethylated in all tissues examined.
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ورودعنوان ژورنال:
- Molecular and cellular biology
دوره 6 1 شماره
صفحات -
تاریخ انتشار 1986